The goal of the Taylor lab is to understand the role of aneuploidy, whole chromosome or chromosome arm imbalance, in the development of cancer. Using functional genomics, genome engineering methods, and analysis of patient genomic data, we study the effects of aneuploidy on signaling and cell fate. Our work spans across many cancer types, with a particular interest in squamous cancers.
Current Lab Members
Laura's goal is to return to graduate school and obtain a PH.D in genetics after gaining experience in the Taylor lab.
Joan Castellano, PhD
PhD, Medicine and Translational Research
I am interested in lung cancer, specifically how aneuploidy effects tumor angiogenesis and organoid generation.
Data Science Initiative Intern
B.S. and M.S. in Biology
Master Candidate in Biostatistics and Statistical Genetics at Columbia University Mailman School of Public Health
My research interests include genetic epidemiology and health informatics. I hope to work in the field of precision medicine one day.
B.S. in Biology
I am interested in research in the area of genomics and/or health care.
Former Lab Members
Sejal Jain, BS
Research Technician (2018-2019)
Current Role: Research Technician at the Dana-Farber Cancer Institut
Valeria Cossich Galicia
Columbia College Class of 2022
B.A. Candidate in Neuroscience
Kim M, Mun H, Sung CO, Jo EJ, Jeon HJ, Lee DS, Kim DK, Chun SM, Choi EK, Jeong SY, Taylor AM, Jain S, Meyerson M, and Jang SJ. “Patient-Derived Lung Cancer Organoids as In Vitro Personalized Models for Therapeutic Screening.” Nat. Commun. 2019 Sept;10:1-15.
Viswanathan SR, Nogueira MF, Buss CG, Krill-Burger JM, Wawer MJ, Malolepsza E, Berger AC, Choi PS, Shih J, Taylor AM, Tanenbaum B, Tamayo P, Pedamallu CS, Cherniack AD, Strathdee CA, Lage K, Carr S, Schenone M, Bhatia SN, Vazquez F, Tsherniack A, Hahn WC, Meyerson M. “Genome-scale Analysis Reveals Paralog Lethality as a Vulnerability of Chromosome 1p Loss in Cancer.” Nat Genet. 2018 Jul;50(7):937-943.
Taylor AM, Shih J, Ha G, Gao GF, Zhang X, Berger AC, Schumacher SE, Wang C, Hu H, Liu J, Lazar AJ, Cancer Genome Atlas Research Network, Cherniack AD, Beroukhim R, Meyerson M. “Genome and Functional Approaches to Cancer Aneuploidy.” Cancer Cell. 2018 Apr 9;33(4):676-689.
Hoadley KA*, Yau C*, Hinoue T*, Wolf DM*, Lazar AJ*, Drill E*, Shen R*, Taylor AM*, Cherniack AD*, Thorsson V*, Akbani R*, Bowlby R*, Wong CK*, Wiznerowicz M, Sanchez-Vega F, Robertson AG, Schneider BG, Lawrence MS, Noushmehr H, Malta TM, Cancer Genome Atlas Network, Stuart JM, Benz CC, Laird PW. “Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.” Cell. 2018 Apr 5;173(2):291-304.
Ding L*, Bailey MH*, Porta-Pardo E*, Thorsson V, Colaprico A, Bertrand D, Gibbs DL, Weerasinghe A, Huang KL, Tokheim C, Cortés-Ciriano I, Jayasinghe R, Chen F, Yu L, Sun S, Olsen C, Kim J, Taylor AM, Cherniack AD, Akbani R, Suphavilai C, Nagarajan N, Stuart JM, Mills GB, Wyczalkowski MA, Vincent BG, Hutter CM, Zenklusen JC, Hoadley KA, Wendl MC, Shmulevich L, Lazar AJ, Wheeler DA, Getz G, Cancer Genome Atlas Research Network. “Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.” Cell. 2018 Apr 5;173(2):305-320.
Campbell JD*, Yau C*, Bowlby R*, Liu Y*, Brennan K*, Fan H*, Taylor AM*, Wang C*, Walter V*, Akbani R*, Byers LA*, Creighton CJ*, Coarfa C*, Shih J, Cherniack AD, Gevaert O, Prunello M, Shen H, Anur P, Chen J, Cheng H, Hayes DN, Bullman S, Pedamallu CS, Ojesina AI, Sadeghi S, Mungall KL, Robertson AG, Benz C, Schultz A, Kanchi RS, Gay CM, Hegde A, Diao L, Wang J, Ma W, Sumazin P, Chiu HS, Chen TW, Gunaratne P, Donehower L, Rader JS, Zuna R, Al-Ahmadie H, Lazar AJ, Flores ER, Tsai KY, Zhou JH, Rustgi AK, Drill E, Shen R, Wong CK, Cancer Genome Atlas Research Network, Stuart JM, Laird PW, Hoadley KA, Weinstein JN, Peto M, Pickering CR, Chen Z, Van Waes C. “Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.” Cell Rep. 2018 Apr 3;23(1):194-212.
Zhang X, Choi PS, Francis JM, Gao GF, Campbell JD, Ramachandran A, Mitsuishi Y, Ha G, Shih J, Vazquez F, Tsherniack A, Taylor AM, Zhou J, Wu Z, Berger AC, Giannakis M, Hahn WC, Cherniack AD, Meyerson M. “Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor.” Cancer Disc. 2018 Jan;8(1):108-125