Cancer Genomics and Epigenomics
The Cancer Genomics and Epigenomics (CGE) program defines the mechanisms, both genetic and epigenetic, that preserve genome integrity in normal cells and create genome instability in cancer cells. Investigators in this group apply their research findings to identify cancer pathways, define new treatment approaches, and improve treatment modalities in chemotherapy, radiotherapy, and immunotherapy.
Major research themes
- Genome plasticity
- Epigenetics
- Computational Genetics & Genomics
Within these themes, members of the program are evaluating how normal and disease DNA repair contributes to genomic instability in cancer and how these pathways can influence the choice of, and response to, anticancer therapies. They are also examining how changes in chromatin elicit tumor developmentand how chromatin modification can be exploited in cancer therapeutics.
