Daniel S. O'Connor, MD

Cardiovascular Disease
Internal Medicine
More specialties
Accepting New Patients
Virtual Visits/Telehealth
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Daniel S. O'Connor, MD, PhD is an Associate Professor of Clinical Medicine at Columbia College of Physicians and Surgeons, Co-director of the Center for CardioOncology, Cardiologist for the Aortic Program and Cardiac Intensivist at Columbia University Medical Center in New York. His areas of expertise include consultative cardiology, critical care cardiology, and non-invasive imaging. Dr. O'Connor is board certified in internal medicine and cardiology.

Dr. O'Connor received his PhD studying vascular and cancer cell biology within the Department of Pharmacology at Yale University. He then received his MD degree at The State University of New York at Brooklyn Medical Center (SUNY Downstate). Dr. O'Connor was an Intern, Resident and Chief Resident at Mount Sinai Medical Center in New York. He then completed his training as a Fellow and Chief Fellow in cardiovascular medicine at Columbia University Medical Center.

Areas of Expertise / Conditions Treated

  • Adult Cardiology
  • Aortic Disease
  • Cardiology Consultation
  • Coronary Artery Disease
  • Critical Care
  • Echocardiography
  • General Cardiology
  • Geriatric Cardiology
  • Heart Valve Disease
  • High Blood Pressure
  • High Cholesterol
  • Sports Cardiology

Academic Appointments

  • Assistant Professor of Medicine at CUMC

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center


  • Male

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Virtual Visits/Telehealth

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Phone Appointments

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161 Fort Washington Avenue
Floor Sixth
New York, NY 10032

Insurance Accepted


  • Aetna Signature Administrators
  • EPO
  • HMO
  • Medicare Managed Care
  • NYP Employee Plan
  • NY Signature
  • POS
  • PPO
  • Student Health

Affinity Health Plan

  • Essential Plan
  • Medicaid Managed Care


  • Medicare Managed Care
  • Special Needs

Amida Care

  • Special Needs


  • EPO
  • Great West (National)
  • HMO
  • Medicare Managed Care
  • POS
  • PPO


  • Medicare Managed Care
  • PPO


  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross/Blue Shield

  • EPO
  • HMO
  • PPO

Empire Blue Cross Blue Shield HealthPlus

  • Child/Family Health Plus
  • Essential Plan
  • Medicaid Managed Care


  • Child/Family Health Plus
  • Leaf (Exchange)
  • Medicaid Managed Care
  • Medicare Managed Care

Local 1199

  • Local 1199

MagnaCare (National)

  • MagnaCare


  • Railroad
  • Traditional Medicare


  • Multiplan

MVP Health Care

  • Child/Family Health Plus
  • Essential Plan
  • HMO
  • Medicaid Managed Care

Quality Health Management

  • Quality Health Management


  • Special Needs


  • Compass (Exchange)
  • Empire Plan
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • Oxford Freedom
  • Oxford HMO
  • Oxford Liberty
  • POS
  • PPO


  • Medicaid Managed Care
  • Medicare Managed Care

World Trade Center Health Plan

  • World Trade Center Health Plan

*Please contact the provider’s office directly to verify that your particular insurance is accepted.

Credentials & Experience

Education & Training

  • MD, SUNY Downstate School of Medicine
  • Internship: Mount Sinai Medical Center
  • Residency: Mount Sinai Medical Center
  • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center

Board Certifications

  • Internal Medicine
  • Cardiovascular Disease

Honors & Awards

  • NIH Training Fellowship. AUGUST 1997- JULY 2000
  • Invited Speaker, Keystone Symposia  “Molecular Mechanism of Apoptosis”, Keystone, Colorado. Title:  “Regulation of Apoptosis at Cell Division by p34cdc2 Phosphorylation of Survivin.” DECEMBER 2001
  • Mount Sinai House Staff Research Day Oral Presentation Award. MAY 2009
  • Richard Gorlin Award for Resident Humanitarianism, Mount Sinai Department of Medicine. JUNE 2009
  • Ralph Kern Fellow in Cardiology, Columbia University Medical Center, New York-Presbyterian Hospital. AUGUST 2012


Selected Publications


O'Connor DS, Schechner JS, Adida C, Mesri M, Rothermel AL, Li F, Nath AK, Pober JS, Altieri DC (2000). Control of apoptosis during angiogenesis by survivin expression in endothelial cells. Am. J. Pathol. 156(2):393-8.

Papapapetropoulus A, Fulton D, Mahboubi K, Kalb RG, O'Connor DS, Li F, Altieri DC, Sessa WC (2000). Angiopoieten-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway. J. Biol. Chem. 275(13):9102-5.

Gratton JP, Fontana J, O'Connor DS, Garcia-Cardena G, McCabe TJ, Sessa WC (2000). Reconstruction of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp 90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1. J. Biol. Chem. 275(29):22268-72.

O'Connor DS, Grossman D, Plescia J, Li F, Zhang H, Villa A, Tognin S, Marchisio PC, Altieri DC (2000). Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc. Natl. Acad. Sci. USA. 97(24):13103-7.

Fortugno P, Wall NR, Giodini A, O'Connor DS, Plescia J, Padgett KM, Tognin S, Marchisio PC, Altieri DC (2002). Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function. J. Cell Sci. 115(Pt 3):575-85.

O'Connor DS, Wall NR, Porter A, Altieri DC (2002). A p34cdc2 survival checkpoint in cancer. Cancer Cell. 2:43-54.

Wall NR, O'Connor DS, Altieri DC (2003). Surpression of survivin phosphorylation on Thr34 by Flavopiridol enhances tumor cell apoptosis. Cancer Res. 63(1): 230-235.

O'Connor DS, Elmariah S, Aledort LM, Pinney SP (2010). A case of disseminated intravascular coagulation complicating Epstein-Barr Virus infection in a cardiac transplant recipient. Transplantation Proc. 42 (5) 1973-75.

Poster Presentations

O'Connor DS, Kaplan A, Park M, Young W, Nawasaka C, Adler E (2010). Notch signaling influence early cardiac conduction system speciation. Keystone Symposium.

O'Connor DS, Green P, Rosner GF, Ginns JN, Rosenbaum MS (2012). Referral rate for pulmonary valve replacement in adult patients with pulmonary stenosis who have undergone childhood valvotomy: A single adult congenital heart center's experience. ACC Chicago.

O'Connor DS, Ginns JN, Quaegebeur J, Bacha E, Rosenbaum MS (2013). Resection of Right Ventricular Outflow Tract Patch during Pulmonary Valve Replacement Improves Right Ventricular Volumes and Ejection Fraction in Patients with Tetralogy of Fallot. ACC San Francisco.