Treatments

If you have uterine cancer, you might have a combination of surgery, radiation, hormonal therapy, or chemotherapy.

Your doctor may recommend surgery to remove your uterus, fallopian tubes, and ovaries, plus a sampling of the important lymph nodes as a first step. Then they’ll send tissue samples to a pathologist to look for abnormalities. We regularly use minimally invasive surgery for hysterectomy. After surgery you might have radiation with or without chemotherapy, depending on the pathology results.

Fertility

Sometimes women are diagnosed with uterine cancer before they’re done having children. If you fall into this category, you might be eligible for nonsurgical management with hormonal therapy that can treat the cancer and preserve your fertility. Hormonal therapy is only utilized in women with early endometrial cancers associated with a favorable prognosis. Women treated with hormonal therapy require frequent monitoring and follow-up.

Young women with endometrial cancer may also be eligible to preserve their ovaries. Ovarian preservation allows for continued hormonal production by the ovaries and avoids symptoms of menopause.

Our gynecologic oncologists have done extensive large-scale safety studies for fertility-sparing surgeries in young women with uterine cancer. We also work with the experts at the Columbia University Fertility Center to find the best options for you.

Surgery

The gynecologic oncologists at Columbia University are national leaders in developing and evaluating minimally invasive surgery for uterine cancer and other gynecologic conditions.

Hysterectomy, or surgical removal of your uterus, is the gold standard for treatment of uterine cancer. Often, your gynecologic oncologist will remove your ovaries and fallopian tubes at the same time, called salpingo-oophorectomy. Additionally, lymph nodes from your pelvis and abdomen are often sampled to determine if the cancer has spread beyond the uterus. Presence of cancer in your lymph nodes indicates the cancer has spread.

Some people with uterine cancer have other significant medical problems that makes surgery unsafe. They might have radiation, sometimes in combination with chemotherapy, instead.

Abdominal (Open) Hysterectomy

Abdominal (open) hysterectomy uses a large incision to access your abdomen. Sometimes the incision is vertical, and sometimes it’s horizontal above your pubic bone, called transverse. If your doctor suspects cancer has spread outside your uterus or if your uterus is significantly enlarged, you’ll likely have this abdominal hysterectomy.

Minimally Invasive Hysterectomy

Minimally invasive hysterectomy uses small incisions to insert a video camera and surgical tools into your abdomen. Your doctor fills your abdomen with gas, then uses the camera to guide the instruments. Your doctor might manipulate the tools, called laparoscopic surgery. Or they might use a surgical robot to assist in surgery.

Lymph Node Evaluation

At the time of hysterectomy, your doctor may also perform biopsies of the lymph nodes to determine whether your cancer has spread beyond the uterus. Lymph node evaluation may be performed by removing the lymph nodes in the pelvis, called a lymphadenectomy. At Columbia University, our gynecologic oncologists frequently use a less invasive technique called a sentinel lymph node biopsy, in which only the nodes at highest risk for cancer are removed.

Chemotherapy and Radiation Therapy

Sometimes cancer spreads beyond your uterus, most frequently to your lymph nodes or abdominal cavity. You’ll learn if this is the case after a pathologist examines tissues removed during surgery for abnormalities.

You may have radiation therapy, sometimes in combination with chemotherapy, if tests show the cancer has spread. You might also have additional treatment if you have factors that increase the risk for cancer to come back, including:

  • Grade (how the cancer appears under the microscopic)
  • Depth of invasion into the wall of the uterus
  • Involvement of the cervix
  • Spread to the lymphatic and vascular channels within the uterus
  • Spread to the ovary or fallopian tube
  • Occurrence of microscopic cancer cells outside of the uterus

Radiation Therapy

Radiation therapy uses high-energy X-rays to destroy cancer cells. Radiation therapy may be part of your treatment plan based on the tumor size, extent, and location. If your doctors determine you are not a candidate for surgery, radiation is usually delivered in combination with chemotherapy with the goal to destroy tumor cells while preserving urinary and bowel function. Your radiation oncologist, who is part of your personal care team, will design an optimal treatment plan for you for the best possible results.

Your radiation treatment plan may include one or a combination of the following types of radiation therapy depending on your disease stage:

External Beam Radiation

External beam radiation is used to deliver radiation to the pelvis. We use conformal techniques to help minimize radiation dose to the bladder, bowel, and rectum while focusing the radiation on areas within the pelvis where tumor cells have or may have spread to. 

Treatments are delivered daily as an outpatient over a few weeks. Each treatment lasts only a few minutes.

Brachytherapy

Brachytherapy, or internal radiation, is a treatment where a radioactive source is placed directly inside or very close to the tumor. It is able to deliver very high doses of radiation while sparing surrounding normal tissues. There are many different types of applicators that may be used to deliver brachytherapy in the pelvis. Your radiation oncologist will meet with you to discuss whether brachytherapy should be part of your treatment plan and what type of brachytherapy would be most appropriate.

Chemotherapy

Chemotherapy uses medications (chemicals) to stop cancer growth and spread and to prevent cancer from recurring by causing rapidly dividing cancer cells to become damaged and die.

Your doctor uses the latest drugs and drug combinations to shrink your cancer or slow or stop its growth.

Chemotherapy is “systemic” medicine—it interferes with all fast-dividing cells in your body. This is why it causes side effects like hair loss. You’ll often get it through an IV in our infusion center. Sometimes it comes in pill form. You’ll have chemotherapy in cycles across a few weeks, with each treatment followed by a rest period.

Clinical Trials

You may qualify to participate in a clinical trial, which is a research study to learn more about promising new treatments or supportive care therapies. The hope is to improve the quality of life and survivorship of cervical cancer patients. You can talk to your care team about whether a clinical trial is an option for you.

Learn More About Clinical Trials

Gynecologic Oncology Survivorship Program

Once you’re finished with treatment, you’ll enter a period of surveillance to make sure your cancer doesn’t return, and if it does, to catch it early. Our experts in the Gynecologic Oncology Survivorship Program create an individualized Survivorship Plan for you. This plan is a comprehensive assessment that includes all the treatment you received, possible late side effects to watch for, a blueprint for future cancer screening, a surveillance plan, and a personalized plan for wellness activities to improve your lifestyle.

Surveillance for uterine cancer is tailored to you. It may include exams and testing. You’ll usually see your gynecologic oncologist instead of your regular gynecologist for these tests.

Recurrence

When cancer comes back after treatment, it’s called recurrence.

Cancer can recur anywhere in your body, including your abdominal cavity, lymph nodes, or vagina or in distant areas such as your lungs or liver. A variety of therapies are available for women with recurrent endometrial cancer, including chemotherapy, hormonal therapy, and immunotherapy. Our team of gynecologic oncologists uses precision medicine to test for specific molecular abnormalities in your cancer to develop a personalized treatment plan.

Symptoms

It’s important to communicate any of these symptoms of recurrence to your gynecologic oncology team:

  • Abdominal pain
  • Bloating
  • Nausea or vomiting
  • Changes in bowel or bladder habits
  • Vaginal bleeding
  • Shortness of breath