RANDOMIZED TRIAL OF LIMB CRYOCOMPRESSION VERSUS CONTINUOUS COMPRESSION VERSUS LOW CYCLIC COMPRESSION FOR THE PREVENTION OF TAXANE-INDUCED PERIPHERAL NEUROPATHY

The purpose of this study is to learn which of the following 3 study approaches is the most helpful to prevent peripheral neuropathy caused by taxane chemotherapy. These approaches will use a study device, called the Paxman Limb Cryocompression System, made of wraps that cool and/or compress your arms and legs. The study will test which of the following combinations of cooling and/or compression to your arms and legs is better at preventing peripheral neuropathy: • Cryocompression (cooling plus moderate and low pressure to your arms and legs) • Continuous compression (moderate, steady pressure to your arms and legs) • Low cyclic compression (low pressure that comes and goes to your arms and legs)

Are you Eligible? (Inclusion Criteria)

• Are you 18 years of age or older? Will you be starting on your first chemotherapy regimen for treatment of a tumor? Are you willing to undergo additional evaluations and to complete questionnaires during your clinic visits?