A Phase I Trial Combining Triapine with Radiation Therapy for Recurrent Glioblastoma or Astrocytoma

Researchers recently found that triapine can make radiation therapy work better against glioblastoma cells and in mice with glioblastoma. Tumors did not grow for a longer time after treatment with triapine along with radiation compared to radiation alone. Triapine has also been tested in people with other types of cancers and has been found to be safe. This study is being done to answer the following question: What is the highest dose of triapine that can be safely and tolerably taken in combination with radiation therapy in patients with recurrent glioblastoma or astrocytoma? We are doing this study because we want to find out if this approach is better or worse than the usual approach for recurrent glioma. The usual approach for patients who are not in a study is treatment with surgery, radiation, or Food and Drug Administration (FDA)-approved drugs such as temozolomide, lomustine, and bevacizumab. Sometimes, combinations of these treatments are used. Your doctor can explain which treatment may be best for you. These treatments can reduce symptoms and may stop the tumor from growing for a few months or longer. The usual approach is proven to help patients with your health condition live longer or prevent the tumor from growing, which may cause worsened or new neurologic symptoms.

Are you Eligible? (Inclusion Criteria)

• Are you 18 years of age or older? Have you been diagnosed with a recurrent astrocytic tumor, such as: Glioblastoma (GBM), astrocytoma, or diffuse midline glioma? Are you able to come to the clinic for regularly scheduled treatment and assessments?