A NON-RANDOMIZED PROSPECTIVE CLINICAL TRIAL COMPARING THE NON-INFERIORITY OF SALPINGECTOMY TO SALPINGO-OOPHORECTOMY TO REDUCE THE RISK OF OVARIAN CANCER AMONG BRCA1 CARRIERS [SOROCk]

The main purpose of this study is to determine if two surgical procedures, the usual approach of removing the fallopian tubes and ovaries and the other approach of removing the fallopian tubes at this time with the plan to remove the ovaries at a later time, are no different for ovarian cancer risk reduction in women with BRCA1 mutations who have completed childbearing. In this study, the removal of fallopian tubes will be compared to the removal of fallopian tubes and ovaries. The study will also examine what factors go into deciding which surgery to have and symptoms after surgery caused by lack of estrogen due to ovary removal.

Are you Eligible? (Inclusion Criteria)

• If you have declined or decided to wait for surgical removal of ovary after proper counseling to clearly explain the standard of care for BRCA1 mutation carriers.
• Must have at least one intact ovary and fallopian tube.
• Must have BRCA1 test results.
• Must be in pre-menopausal phase, if you have had a previous hysterectomy with atleast one ovary kept, you can participate.
• Must not have had diagnosis of cancer and have received treatment in past 12 months.