Melanoma Margins Trial (MelMarT): A Phase III, Multi-Centre, Multi-National Randomised Control Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma


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During surgery for melanoma, the skin cancer and a small margin of healthy tissue around it are removed. This study will investigate how much skin should be removed from around the melanoma. Currently, doctors do not know how much skin to remove from around a melanoma to reduce the chances of the melanoma coming back. This study is being done to answer the following questions: Is a 1-centimeter margin as good as a 2-centimeter margin at reducing the risk of melanoma returning? Does having less than a 2-centimeter margin of skin removed cause fewer side effects and improve quality of life? This study is being done to find out if this approach is better or worse than the usual approach for melanoma surgery. The usual approach is defined as care most people get for melanoma.

Are you Eligible? (Inclusion Criteria)

  • Are you 18 years of age or older? Have you been diagnosed with cutaneous melanoma and your doctor has suggested surgery as a potential treatment option?

Specialty Area(s)

Skin cancers, Melanoma

Principal Investigator

Profile Headshot
  • Director, Breast Surgery Fellowship

Trial Location(s)

CUIMC/Herbert Irving Pavilion
161 Fort Washington Avenue
New York, NY 10032