AGCT1531 - A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors

Contact:

NCT Number:

Protocol:

AAAR4300

Study Status:

Active/Enrolling

Population:

Pediatrics/Adult

Phase:

III

This partially randomized phase III trial studies how well active surveillance, bleomycin, carboplatin, etoposide, or cisplatin work in treating pediatric and adult patients with germ cell tumors. Active surveillance may help doctors to monitor subjects with low risk germ cell tumors after their tumor is removed. Drugs used in chemotherapy, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.

Are you Eligible? (Inclusion Criteria)

  • Subjects may be up to 49 years of age at the time of study entry.
  • Patients must have been diagnosed with a primary extracranial germ cell tumor.
  • Subjects must be considered low risk or standard risk to participate.
  • Patients must also meet all eligibility criteria as outlined in the study protocol.

Specialty Area(s)

Childhood and Adolescent Cancers (Pediatric), Pediatric: Solid Tumors

Principal Investigator