Sam Yoon, MD

Surgery, Surgical Oncology, Cancer Care
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Dr. Sam S. Yoon is the Chief of the Division of Surgical Oncology and Vice-Chair of Surgical Oncology Research and Education in the Department of Surgery at Columbia University Irving Medical Center (CUIMC).

Dr. Yoon is a national and international expert in the treatment of patients with sarcomas and other soft tissue tumors, gastric (stomach) and gastroesophageal cancers, gastrointestinal stromal tumors (GISTs), and melanoma. He also has over 18 years of experience in the treatment of other gastrointestinal and abdominal tumors, hepatobiliary tumors, neuroendocrine/adrenal tumors, lymphomas, and spleen tumors. He has been the principal investigator of several clinical trials examining novel treatment strategies and given numerous invited national and international lectures in relation to these cancers. Several of these trials have investigated the treatment of sarcomas, especially abdominal/retroperitoneal sarcomas, with advanced radiation techniques such as proton beam radiation and aggressive surgical resection to minimize local recurrence.

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Dr. Yoon was an early advocate for minimally invasive robotic surgery and has performed over 300 robotic procedures including robotic gastrectomies (stomach removal). He has one of the world’s largest experiences in performing prophylactic total gastrectomies for patients with hereditary diffuse gastric cancer (HDGC syndrome) secondary to germline CDH1 mutation. He pioneered a technique for connection of the small bowel to the esophagus after total gastrectomy that is used by former surgical trainees and colleagues throughout the country due to its extremely low leakage rate.

Dr. Yoon graduated from Harvard University and received his M.D. from the University of California at San Diego. He completed his residency in general surgery at Massachusetts General Hospital and his fellowship in surgical oncology at the Memorial Sloan-Kettering Cancer Center. He was an Associate Professor of Surgery at Massachusetts General Hospital and Harvard Medical School before joining the staff at Memorial Sloan-Kettering Cancer Center in 2012. Dr. Yoon was an Attending Surgeon in the Division of Gastric and Mixed Tumors at Memorial Sloan Kettering Cancer Center and a Professor of Surgery at Weill Cornell Medical College before joining CUIMC in 2021.

Dr. Yoon’s main research interests are in cancer stem cells and targeted biological agents in combination with chemotherapy and radiation therapy. His laboratory has been funded by the National Institutes of Health/National Cancer Institute for 18 years and strives to translate new research discoveries into the clinic. Dr. Yoon is also part of multi-institution research groups funded by Stand Up To Cancer and the DeGregorio Family Foundation to discover early diagnostics and new therapies for gastric cancer. His clinical and research efforts have led to over 150 original research articles, book chapters, and reviews.

Visit The Yoon Lab

For a complete list of publications, please visit NCBI.

Areas of Expertise / Conditions Treated

  • Adrenal Cancer
  • Desmoid Tumors
  • Gastric Cancer
  • Gastroesophageal Junction Cancer
  • Gastrointestinal Cancer
  • Gastrointestinal Malignancies
  • Gastrointestinal Tumors
  • Laparoscopic Surgery
  • Liver Cancer
  • Liver Surgery
  • Lymph Nodes
  • Melanoma
  • Melanoma Surgery
  • Metastatic Cancer
  • Minimally Invasive Surgery
  • Nerve Sheath Tumors
  • Neuroendocrine Carcinoma
  • Neuroendocrine Tumor
  • Robotic Surgery
  • Sarcoma
  • Schwannomas
  • Stomach Cancer
  • Surgical Oncology

Academic Appointments

  • Professor of Surgery at CUMC

Administrative Titles

  • Chief, Division of Surgical Oncology
  • Vice-Chair of Surgical Oncology Research and Education

Hospital Affiliations

  • NewYork-Presbyterian Lawrence Hospital
  • NewYork-Presbyterian / Columbia University Irving Medical Center
  • NewYork-Presbyterian Hudson Valley Hospital


  • Male

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1 Pondfield Road
Bronxville, NY 10708
1985 Crompond Road
Building E
Cortlandt Manor, NY 10567
25 Rockwood Place
Suite 330
Englewood, NJ 07631
Disabled Accessible
Public Transit Accessible
177 Ft. Washington Avenue
New York, NY 10032

Insurance Accepted


  • Medicare Managed Care
  • Student Health

Affinity Health Plan

  • Essential Plan
  • Medicaid Managed Care


  • Medicare Managed Care
  • Special Needs

Amerigroup of New Jersey

  • New Jersey Services (Medicaid Managed Care)

AmeriHealth of New Jersey

  • EPO - New Jersey Services
  • HMO - New Jersey Services
  • POS - New Jersey Services
  • PPO - New Jersey Services

Amida Care

  • Special Needs

Capital District Physician Health Plan (CDPHP)

  • EPO
  • HMO
  • PPO


  • EPO
  • Great West (National)
  • HMO
  • POS
  • PPO


  • Medicare Managed Care
  • PPO


  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
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  • Medicare Managed Care

Empire Blue Cross Blue Shield HealthPlus

  • Child/Family Health Plus
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Fidelis Care

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  • Medicaid Managed Care
  • Medicare Managed Care


  • Child/Family Health Plus
  • Leaf (Exchange)
  • Medicaid Managed Care
  • Medicare Managed Care

Horizon Blue Cross Blue Shield

  • EPO - New Jersey Services
  • EPO - New York Services
  • HMO - New Jersey Services
  • HMO - New York Services
  • POS - New Jersey Services
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  • PPO - New Jersey Services
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Local 1199

  • Local 1199

MagnaCare (National)

  • MagnaCare


  • Railroad
  • Traditional Medicare


  • Multiplan

MVP Health Care

  • Child/Family Health Plus
  • Essential Plan
  • HMO
  • Medicaid Managed Care


  • HMO - New Jersey Services
  • POS - New Jersey Services
  • PPO - New Jersey Services


  • Special Needs


  • Compass (Exchange)
  • Empire Plan
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • POS
  • PPO


  • SelectHealth


  • Medicaid Managed Care
  • Medicare Managed Care
  • New Jersey Services (Medicare Managed Care)

*Please contact the provider’s office directly to verify that your particular insurance is accepted.

Credentials & Experience

Honors & Awards

  • Best Doctors in America, 2010-2011, 2017-2020
  • American College of Surgeons/Society for Surgery of the Alimentary Tract Health Policy Scholar Award, 2019-2020
  • Runner-up, Memorial Sloan Kettering Cancer Center Surgical Oncology Fellows’ Teacher of the Year, 2018-2019 and 2019-2020
  • 2017 Paper of the Year Award, New England Surgical Society, 2017
  • Josef E. Fischer International Traveling Fellowship Award for Surgeons in Academic Practice, Society for Surgery of the Alimentary Tract, 2012
  • Clinical Investigator Award, Society for Surgical Oncology, 2009-2011


Selected Publications

  • Lin JX, Yoon C, Desiderio J, Yi BC, Li P, Zheng CH, Parisi A, Huang CM, Strong VE, Yoon SS. Development and validation of a staging system for gastric adenocarcinoma following neoadjuvant chemotherapy and gastrectomy with D2 lymphadenectomy. British Journal of Surgery 106(9):1187-1196, Aug 2019.
  • Lee JH, Chang KK, Yoon C, Tang LH, Strong VE, Yoon SS. Lauren histologic type is the most important factor associated with pattern of recurrence following resection of gastric adenocarcinoma. Annals of Surgery 267(1):105-13, Jan 2018.
  • Chang KK, Patel MS, Yoon SS. Linear-stapled side-to-side esophagojejunostomy with hand-sewn closure of the common enterotomy after therapeutic and prophylactic total gastrectomy. Journal of Gastrointestinal Surgery 21(4):712-722, Apr 2017.
  • Kelly KJ*, Yoon SS*; Kuk D, Qin LX, Duklesk K, Chang KK, Chen YL, DeLaney TF,B Brennan MF, Singer S. Comparison of perioperative radiation therapy and surgery versus surgery alone in 204 patients with primary retroperitoneal sarcoma: a retrospective two-institution study. Annals of Surgery 262(1):156-62, Jul 2015. *Equal contribution first-authors.
  • Yoon SS, Duda DG, Karl DL, Kim TM, Kambad akone AR, Chen YL, Rothrock C, Rosenberg AE, Nielsen GP, Kirsch DG, Choy E, Harmon DC, Hornicek FJ, Dreyfuss J, Ancukiewicz M, Sahani DV, Park PJ, Jain RK, DeLaney TF. *Phase II study of neoadjuvant bevacizumab and radiation therapy for resectable soft tissue sarcomas. International Journal of Radiation Oncology, Biology, Physics 81(4):1081-90, Nov 15, 2011. *Article featured on journal cover.