Ji-Yeon Shin, PhD

  • Assistant Professor of Medical Sciences (in Medicine) at CUMC
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Dr. Shin obtained her BS and MS from South Korea. After she moved to US, she received her PhD from Emory University where she studied non-cell autonomous contribution in the pathophysiology of Huntington’s disease. Dr. Shin did research in neurogenetics as a postdoctoral scientist at UCSF. After she moved to New York, she did another postdoctoral research with Drs. William Dauer and Howard Worman to study the roles of nuclear envelope proteins in development and straited muscle diseases. Dr. Shin was appointed as an assistant professor of Medical Sciences in the Department of Medicine in 2019.

Academic Appointments

  • Assistant Professor of Medical Sciences (in Medicine) at CUMC


  • Female


The long-term research goal of the Shin lab is to understand the cellular roles of nuclear envelope proteins in development, metabolism and tumorigenesis. The lab aims to translate the acquired knowledge into developing therapeutic approaches for various human diseases linked to nuclear envelope protein dysfunction. To accomplish this goal, the lab has been employing various methods including cell biology, biochemistry, mouse genetics, stem cell biology and multi-omics approaches.

One of the research directions is to delineate the roles of a nuclear envelope protein complex in hepatic steatosis and neoplasia. In a collaborative effort, the group discovered that the nuclear envelope localized LAP1-torsinA complex is responsible for hepatic lipid homeostasis whose abnormality is linked to steatotic liver diseases including steatohepatitis development (Shin et al. JCI, 2019). The current research focus is to investigate the underlying cellular and molecular mechanisms using mouse models in which LAP1 or torsinA is depleted from hepatocytes and isolated primary hepatocytes. The lab is developing engineered iPSC-derived hepatocytes to further study cellular mechanisms of lipid regulation by nuclear envelope proteins in human cells.


  • New York Obesity Nutrition Research Center pilot grant, Shin (PI) 2017-2019
  • Columbia University Digestive and Liver Diseases Research Center Pilot grant, Shin (PI) 2020-2021
  • Gilead Sciences Research Scholars Award, Shin (PI) 2020- 2022
  • American Association for the Study of Liver Diseases Pinnacle Research Award, Shin (PI) 2021-2024
  • R01 CA283566-01 NIH/NCI, Shin (PI) 2023-2028

Selected Publications

  • Shin JY, Hernandez-Ono A, Fedotova T, Östlund C, Lee MJ, Gibeley SB, Liang CC, Dauer WT, Ginsberg HN, Worman HJ. Nuclear envelope-localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis. J. Clin. Invest. 2019;130:4885-4900 
  • Östlund C, Hernandez-Ono A, Shin JY. The nuclear envelope in lipid metabolism and pathogenesis of NAFLD. Biology 2020;9:338  
  • Östlund C, Hernandez-Ono A, Turk SJ, Dauer WT, Ginsberg HN, Worman HJ, Shin JY. Intranuclear lipid droplets in hepatocytes deficient in nuclear envelope protein lamina-associated polypeptide 1. J Lipid Res 2022; 63:100277 (Featured on cover page) 
  • Hernandez-Ono A, Zhao YP, Murray JW, Östlund C, Lee MJ, Dauer WT, Worman HJ*, Ginsberg HN*, Shin JY*. Functional interaction of torsinA and its activators in liver lipid metabolism. bioRxiv 2023.06.21.545957 [Preprint] DOI: 10.1101/2023.06.21.545957 [*Co-corresponding authors]