Jean Gautier, PhD

  • Professor of Genetics and Development (in the Institute for Cancer Genetics)
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Academic Appointments

  • Professor of Genetics and Development (in the Institute for Cancer Genetics)

Administrative Titles

  • Leader, Cancer Genomics and Epigenomics Program, Herbert Irving Comprehensive Cancer Center


Jean Gautier studies the mechanisms responsible for the maintenance of genome stability. The laboratory employs diverse experimental approaches to elucidate the causes and the role of genome instability in cancer. Cell-free extracts derived from the egg of the frog Xenopus laevis are used as a simple model system to study processes that govern genome stability, including DNA replication control, DNA repair, and the cellular response to DNA damage. In addition, cultured normal and tumor cells and mouse models are exploited to analyze biological responses to DNA damage. The Gautier laboratory use a range of techniques including biochemistry, proteomics, live-cell imaging, super-resolution microscopy, Hi-C and genome-wide translocation sequencing.

Selected Publications

  1. Dual-Color Plasmonic Nanosensor for Radiation Dosimetry
    Tao Y, Li M, Liu X, Leong KW, Gautier J, Zha S
    ACS Appl Mater Interfaces. 2020.
    PMID: 32337977, DOI: 10.1021/acsami.0c03001
  2. Assembling nuclear domains: Lessons from DNA repair
    Schrank B, Gautier J
    J Cell Biol. 2019.
    PMID: 31324649, DOI: 10.1083/jcb.201904202
  3. Nuclear ARP2/3 drives DNA break clustering for homology-directed repair
    Schrank BR, Aparicio T, Li Y, Chang W, Chait BT, Gundersen GG, Gottesman ME, Gautier J
    Nature. 2018.
    PMID: 29925947, DOI: 10.1038/s41586-018-0237-5
  4. Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway
    Kato N, Kawasoe Y, Williams H, Coates E, Roy U, Shi Y, Beese LS, Schärer OD, Yan H, Gottesman ME, Takahashi TS, Gautier J
    Cell Rep. 2017.
    PMID: 29091773, DOI: 10.1016/j.celrep.2017.10.032
  5. MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts
    Aparicio T, Baer R, Gottesman M, Gautier J
    J Cell Biol. 2016.
    PMID: 26880199, DOI: 10.1083/jcb.201504005
  6. MYC is a critical target of FBXW7
    Sato M, Rodriguez-Barrueco R, Yu J, Do C, Silva JM, Gautier J
    Oncotarget. 2015.
    PMID: 25669969, DOI: 10.18632/oncotarget.3203
  7. Cdc45 is a critical effector of myc-dependent DNA replication stress
    Srinivasan SV, Dominguez-Sola D, Wang LC, Hyrien O, Gautier J
    Cell Rep. 2013.
    PMID: 23643534, DOI: 10.1016/j.celrep.2013.04.002
  8. Activation of DSB processing requires phosphorylation of CtIP by ATR
    Peterson SE, Li Y, Wu-Baer F, Chait BT, Baer R, Yan H, Gottesman ME, Gautier J
    Mol Cell. 2013.
    PMID: 23273981, DOI: 10.1016/j.molcel.2012.11.020
  9. Replication-independent repair of DNA interstrand crosslinks
    Williams HL, Gottesman ME, Gautier J
    Mol Cell. 2012.
    PMID: 22658724, DOI: 10.1016/j.molcel.2012.05.001
  10. Double-strand break end resection and repair pathway choice
    Symington LS, Gautier J
    Annu Rev Genet. 2011.
    PMID: 21910633, DOI: 10.1146/annurev-genet-110410-132435
  11. Checkpoint signaling from a single DNA interstrand crosslink
    Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J
    Mol Cell. 2009.
    PMID: 19748363, DOI: 10.1016/j.molcel.2009.08.014
  12. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
    Dupré A, Boyer-Chatenet L, Sattler RM, Modi AP, Lee JH, Nicolette ML, Kopelovich L, Jasin M, Baer R, Paull TT, Gautier J
    Nat Chem Biol. 2008.
    PMID: 18176557, DOI: 10.1038/nchembio.63
  13. Non-transcriptional control of DNA replication by c-Myc
    Dominguez-Sola D, Ying CY, Grandori C, Ruggiero L, Chen B, Li M, Galloway DA, Gu W, Gautier J, Dalla-Favera R
    Nature. 2007.
    PMID: 17597761, DOI: 10.1038/nature05953
  14. ATR and ATM regulate the timing of DNA replication origin firing
    Shechter D, Costanzo V, Gautier J
    Nat Cell Biol. 2004.
    PMID: 15220931, DOI: 10.1038/ncb1145
  15. An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication
    Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J
    Mol Cell. 2003.
    PMID: 12535533, DOI: 10.1016/s1097-2765(02)00799-2