A Phase II Randomized Study of Ibrutinib and Rituximab with or without Venetoclax in Previously Untreated Waldenström's Macroglobulinemia (WM)/Lymphoplasmacytic Lymphoma (LPL)


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The purpose of this study is to compare the usual treatment alone to using venetoclax plus the usual treatment. The addition of venetoclax to the usual treatment could shrink the cancer. But, it could also cause side effects. This study will help the study doctors find out if this different approach is better than the usual approach. To decide if it is better, the study doctors will be looking to see if the drug combination of venetoclax with ibrutinib and rituximab shrinks and prevents the return of Waldenström's Macroglobulinemia/Lymphoplasmacytic Lymphoma compared to the usual approach.

Are you Eligible? (Inclusion Criteria)

  • Are you 18 years of age or older?
  • Have you been diagnosed with Waldenström’s macroglobulinemia(WM) /
  • Lymphoplasmacytic Lymphoma (LPL)?
  • Are you able to make regularly scheduled visits to the clinic for treatment and
  • examinations?

Specialty Area(s)

Non-Hodgkin's Lymphoma, Immunotherapy

Principal Investigator

Trial Location(s)

CUIMC/Herbert Irving Pavilion
161 Fort Washington Avenue
New York, NY 10032