A Phase 1/2 Study of REGN4018 (A MUC16xCD3 Bispecific Antibody) Administered Alone or in Combination with Cemiplimab in Patients with Recurrent Ovarian Cancer or Other Recurrent MUC16+ Cancers

Contact:

NCT Number:

Protocol:

AAAR8226

Study Status:

Active/Enrolling

Population:

Adult

Phase:

I/II

The main purpose of this study is to: • Learn about the safety of REGN4018 and to find out what dose of REGN4018 can be given alone or in combination with cemiplimab to research subjects with ovarian cancer without too many side effects. • The study will also look at the levels of REGN4018 and/or cemiplimab in the body and measure how well your body can remove the study drug(s). This is called pharmacokinetics. • The study will also look at any signs that REGN4018 alone or with cemiplimab can treat cancer.

Are you Eligible? (Inclusion Criteria)

  • Do you have ovarian cancer?
  • Are you a woman age 18 years or older?
  • Are you willing and able to comply with clinic visits and study-related procedures, including, but not limited to, undergoing study biopsies?

Specialty Area(s)

Ovarian Cancer, Immunotherapy

Principal Investigator

Profile Headshot
  • Co-Director, Hereditary Breast and Ovarian Cancer Program
  • Director of Clinical Operation, Gyn Oncology

Trial Location(s)

CUIMC/Herbert Irving Pavilion
161 Fort Washington Avenue
New York, NY 10032