Locoregional breast cancer recurrence following targeted intraoperative radiotherapy (IORT) for ductal carcinoma in situ (DCIS)

The purpose of this study is to examine whether targeted Intraoperative Radiotherapy (IORT) is as effective as external beam radiation in treating DCIS and preventing it from returning. In addition, we will evaluate the side effects of IORT (toxicity), imaging changes, cosmetic appearance of the breast and your quality of life. In this study, subjects with DCIS will have IORT during with breast conserving surgery. Follow-up duration is 5 years.

Are you Eligible? (Inclusion Criteria)

• To be eligible for this trial, patients must be:
• Female 18 years old or older with DCIS suitable for breast conserving surgery and radiotherapy
• single tumor size less than or equal to 2 cm , no axillary lymph node involvement and no metastases
• amenable to follow-up for at least 5 years.
• No prior treatment